Below you find clinical studies about the LED Light Treatment device from Quantum Devices inc. in USA, the system they started producing on mission from NASA. If you have any questions contact Marcus Odell, +46 (0)704-55 48 22.

FacialRejuvenationABSTRACT: Recently, we introduced into the conventional catalogue of biological aging a new determinant: ordered interfacial water layers. The discovery of their tunability with skin-tolerated levels of 670 nm light inspired a model, which suggested that the light, by interaction with ordered interfacial water layers in the extracellular matrix, would reverse elastin degeneration.

Effects of Low-Level Light Therapy on Hepatic Antioxidant Defense in Acute and Chronic Diabetic RatsABSTRACT: Diabetes causes oxidative stress in theliver and other tissues prone to complications. Photobiomodulationby near infrared light (670 nm) has been shown to accelerate diabetic wound healing, improve recovery from oxidative injury in the kidney, and attenuate degeneration in retina and optic nerve. The present study tested the hypothesis that 670 nm photobiomodulation, a low-level light therapy, would attenuate oxidative stress and enhance the antioxidant protection system in the liver of a model of type I diabetes.

Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injuryby a nitric oxide dependent mechanismABSTRACT: Photobiomodulation with near infrared light (NIR) provides cellular protection in various disease models. Previously, infrared light emitted by a low-energy laser has been shown to significantly improve recovery from ischemic injury of the canine heart. The goal of this investigation was to test the hypothesis that NIR(670 nm) from light emitting diodes produces cellular protection against hypoxia and reoxygenation-induced cardiomyocyte injury.

Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity
ABSTRACT: Parkinson’s disease (PD) is a movement disorder caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to nigrostriatal degeneration. The inhibition of mitochondrial respiratory chain complex I and oxidative stress-induced damage have been implicated in the pathogenesis of PD. The present study used these specific mitochondrial complex I inhibitors (rotenone and 1-methyl-4-phenylpyridinium or MPP+) on striatal and cortical neurons in culture. The goal was to test our hypothesis that pretreatment with near-infrared light (NIR) via light-emitting diode (LED) had a greater beneficial effect on primary neurons grown in media with rotenone or MPP+ than those with or without LED treatment during exposure to poisons.
Modulation of rat pituitary growth hormone by 670 nm light
ABSTRACT: In rat pituitary somatotrophs, cytochrome oxidase is co-packaged with growth hormone (GH) in some storage granules. Because this enzyme is thought to be the molecular photoacceptor of red-near infrared light, and because exposure of diverse tissue systems to 670 nm visible light affects their biological responses (e.g., wound healing), we tested the idea that exposure of rat pituitary cells, rat hemi-pituitary glands and rat pituitary homogenates to 670 nm light in vitro might alter GH storage and/or release.
Near-infrared light via Light-Emitting-Diode treatment is therapeutic against rotenone-and1-methyl-4-phenylpyridinium Ion-induced neurotoxicity
ABSTRACT: Parkinson’s disease is a common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mitochondrial dysfunction has been strongly implicated in the pathogenesis of Parkinson’s disease. Thus, therapeutic approaches that improve mitochondrial function may prove to be beneficial. Previously, we have documented that near-infrared light via light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCNinduced apoptotic cell death. The current study tested our hypothesis that LED treatment can protect neurons from both rotenone- and MPP-induced neurotoxicity.
Photobiomodulation for the Treatment of Retinal Injury and Retinal Degenerative Diseases
ABSTRACT: Retinal injury and retinal degenerative diseases are a leading causes of visual impairment in the developed world. Mitochondrial dysfunction and oxidative stress play key roles in the pathogenesis of retinal injury and disease. The development and testing of strategies designed to improve mitochondrial function and attenuate oxidative stress are essential for combating retinal disease. One strategy involves the use of photobiomodulation. Photobiomodulation, low-energy photon irradiation by light in the far-red to nearinfrared(NIR) range using low energy lasers or light-emitting diode (LED) arrays, has been applied clinically in the treatment soft tissue injuries and acceleration of wound healing for more than 30 years. The therapeutic effects of photobiomodulation have been hypothesized to be mediated by intracellular signaling mechanisms triggered by the interaction of far-red to NIR photons with the mitochondrial photoacceptor molecule cytochrome oxidase which culminate in improved mitochondrial energy metabolism, increased synthesis of cytoprotective factors and cell survival.


Photomodulation of Cytochrome Oxidase
ABSTRACT: Photobiomodulation by red to near infrared light is believed to activate mitochondrial respiratory chain components promoting cytoprotecton. Recent studies in our laboratory demonstrate that the action spectrum for stimulation of cytochrome oxidase activity and cellular ATP parallels the nearinfrared absorption spectrum of cytochome oxidase and that 660–680 nm irradiation upregulates cytochrome oxidase activity in cultured neurons.
Embryonic Growth and Hatching Implications of Developmental 670-nm Phototherapy and Dioxin Co-exposure
ABSTRACT: We assessed the effect of 670-nm light therapy on growth and hatching kinetics in chickens (Gallusgallus) exposed to dioxin. Background Data: Photobiomodulation has been shown to stimulate signaling pathways resulting in improved energy metabolism, antioxidant production, and cell survival. In ovo treatment with 670-nm light-emitting diode (LED) arrays improves hatching success and increases hatchling size in control chickens. Under conditions where developmental dioxin exposure is above the lethality threshold (100ppt), phototherapy attenuates dioxin-induced early embryonic death. We hypothesized that 670-nm LEDtherapy would attenuate dioxin-induced developmental anomalies and increase hatching success.
Stressed Cells Survive Better with Light
ABSTRACT: Biostimulatory effects achieved in various biosystems irradiated with light lead us to recommend photobiostimulation for the compensation of external stress stimuli in tissue engineering, as well as in cellular imaging. Bioengineered cell assemblies and tissues are exposed to extreme environmental stress states during their transfer from artificial milieus into the body and in the first phase of their implantation. Similarly, cellular imaging via optical methods could represent a major stress impact to the biosystems examined, in particular, in temporally extended investigations.
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